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Keep an eye on Carefully (1)istradefylline will improve the degree or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.diazepam will enhance the level or influence of ruxolitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.apalutamide will minimize the level or impact of diazep